Dr. Jin Nam
Assistant Professor
Department of Bioengineering

Ph.D., 2006 The Ohio State University

CONTACT
Office : (951) 827-2064
Fax : (951) 827-6416
e-mail : jin.nam@ucr.edu
RESEARCH INTERESTS
Skeletal diseases such as osteoarthritis and osteoporosis afflict more than 40% of all adults and more than 70% of aging populations. Exercise has been shown to prevent the initiation of and treat early stages of these diseases. Based on these observations, our laboratory focuses on the utilization of intrinsic (scaffolding) and extrinsic (applied forces) biomechanical stimulation on mesenchymal stem cells in order to develop methodologies for repairing damaged skeletal tissues. Specifically, we investigate how to control mesenchymal stem cell differentiation to chondrocytes and osteoblasts for cartilage and bone regeneration through the development of mechano-responsive polymeric scaffolds and the application of biomechanical stimulation to such engineered skeletal tissues. Current projects include the development of 3D-scaffolds having mechanical microenvironment gradients to induce multi-directional stem cell differentiation to terminal phenotypes of chondrocytes and osteoblasts. In addition, magnitude-dependent differentiation of stem cells under biomechanical stimulaiton is investigated to enhance the generation of engineered osteochondral tissue constructs.

HONORS AND AWARDS

  • Dean's Award for Excellence in Research - College of Dentistry, The Ohio State University (2011)

  • Young Investigator Award - Osteoarthritis Research Society International (2010)

  • Ruth L. Kirschstein National Research Service Award (2010)

  • Finalist for Young Investigator Poster Competition in the Tissue Engineering and Regenerative Medicine Society-North America meeting (2008)

  • Young Investigator Award - Osteoarthritis Research Society International (2007)

  • The Honor Society of Phi Kappa Phi (2004)

  • The International Honor Society of Alpha Sigma Mu (2001)

SELECTED PUBLICATIONS

See publications on PubMed

J. Nam, P. Perera, J. Liu, B. Rath, J. Deschner, R. Gassner, T. Butterfield and S. Agarwal (in press) Regulation of transcriptome-wide gene expression during the progression of monoiodoacetate-induced arthritis, PLoS ONE

B. Rath, J. Nam, J. Deschner, J. Schaumburger, M. Tingart, S. Grässel, J. Grifka and S. Agarwal (2011) Biomechanical forces exert anabolic effects on osteoblasts by activation of SMAD 1/5/8 through type 1 BMP receptor, Biorheology 48(1), 37-48

J. Nam, P. Perera, J. Liu, L. Wu, T. Butterfield and S. Agarwal (2011) Transcriptome-wide gene regulation by gentle treadmill walking during the progression of monoiodoacetate induced arthritis, Arthritis and Rheumatism 63(6), 1613-25 *selected for journal cover image

J. Nam, J. Johnson, J. Lannutti and S. Agarwal (2011) Modulation of embryonic mesenchymal progenitor cell differentiation via control over pure mechanical modulus in electrospun nanofibers, Acta Biomaterialia 7(4), 1516-24

P. Perera, E. Wypasek, S. Madhavan, B. Rath-Deschner, J. Liu, J. Nam, B. Rath, M. Anghelina, Y. Huang, J. Deschner, N. Piesco, C. Wu and Agarwal S (2010) Integrin-linked kinase, H-RAS, ERK 1/2-dependent mechanosignaling mechanisms control Sox-9, Vegf and c-Myc expression and cell proliferation in articular chondrocytes, Arthritis Research and Therapy 12(3), R106

J. Nam, B. Aguda, B. Rath and S. Agarwal (2009) Biomechanical thresholds regulating inflammation through the NF- B pathway: experiments and modeling, PLoS ONE 4(4) e5262

A. Veleva, D. Heath, J. Johnson, J. Nam, C. Patterson, J. Lannutti and S. Cooper (2009) Interactions between endothelial cells and electrospun methacrylic terpolymer fibers for engineered vascular replacements, Journal of Biomedical Materials Research A 91A(4), 1131-1139

Y. Zhao, H. Zeng, J. Nam and S. Agarwal (2009) Fabrication of skeletal muscle constructs by topographic activation of cell alignment, Biotechnology and Bioengineering 102(2), 624-31 *selected for journal cover image

J. Nam, B. Rath, T. Knobloch, J. Lannutti and S. Agarwal (2009) Novel electrospun scaffolds for the molecular analysis of chondrocytes under dynamic compression, Tissue Engineering 15(3), 513-23

M. Anghelina, D. Sjostrom, P. Perera, J. Nam, T. Knobloch and S. Agarwal (2008) Regulation of biomechanical signals by NF-?B transcription factors in chondrocytes, Biorheology 45(3-4), 245-56

B. Rath, J. Nam, J. Lannutti and S. Agarwal (2008) Compressive forces induce osteogenic gene expression in calvarial osteoblasts, Journal of Biomechanics 41(5), 1095-103

T. Knobloch, S. Madhavan, J. Nam, S. Agarwal Jr. and S Agarwal (2008) Regulation of chondrocytic gene expression by biomechanical signals, Critical Reviews in Eukaryotic Gene Expression 18(2), 139-150

J. Nam, Y. Huang, S. Agarwal and J. Lannutti (2008) Materials selection and residual solvent retention in biodegradable electrospun fibers, Journal of Applied Polymer Science, 107(3), 1547-1554

H. Choi, J. Johnson, J. Nam, D. Farson and J. Lannutti (2007) Structuring electrospun polycaprolactone nanofiber tissue scaffolds by femtosecond laser ablation, Journal of Laser Applications, 19 (4), 225-231

J. Nam, Y. Huang, S. Agarwal and J. Lannutti (2007) Improved cellular infiltration in electrospun fiber via engineered porosity, Tissue engineering, 13(9), 2249-2257

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