Dr. Kaustabh Ghosh
Assistant Professor
Department of Bioengineering

Ph.D., 2006 State University of New York (SUNY), Stony Brook
Postdoctoral Fellowship, 2011 Harvard Medical School

CONTACT
Phone : (951) 827-4203
Fax : (951) 827-6416
e-mail : kghosh@engr.ucr.edu
RESEARCH INTERESTS

Our laboratory is pursuing interdisciplinary research at the interface of basic and applied science that is aimed at (1) understanding how cell- and extracellular matrix (ECM)-dependent mechanical cues regulate blood vessel formation (neovascularization) and function in both health and disease, and (2) developing instructive biomaterials that leverage the body's endogenous bone marrow-derived vascular stem/progenitor cells to promote in situ neovascularization and tissue regeneration. To achieve this goal, our lab integrates the multidisciplinary principles and techniques related to cellular and tissue biomechanics, vascular biology, biomaterials science and regenerative medicine. Since both newly forming and mature tissues rely critically on blood vessels for efficient nutrient and oxygen supply, this research has important therapeutic implications for promoting tissue regeneration, ameliorating post-ischemic tissue hypoxia and improving the functionality of artificially engineered tissues and organs.

More information on Ghosh Research Group (link to www.engr.ucr.edu/faculty/bio/kghosh.html )

HONORS AND AWARDS
2011 Invited Speaker - The Lindbergh Lectures, University of Wisconsin-Madison

2008 Postdoctoral Training Grant, NIH/NIBIB (T32) Interdisciplinary Research Training Program

2006 President's Award to Distinguished Doctoral Students, SUNY Stony Brook

2004 Graduate Student Scholarship, New Jersey Center for Biomaterials

2004 Outstanding Mentor Award, Siemens Foundation

1999-2001 Undergraduate Merit Scholarship, National Institute of Technology, Warangal, INDIA


SELECTED PUBLICATIONS

See publications on PubMed (link to http://www.ncbi.nlm.nih.gov/pubmed?term=kaustabh%20ghosh)

Ghosh K, Khajavi M, Adini A (2011, in press). Quantitative study of in vivo angiogenesis and vasculogenesis using Matrigel-based assays. In: Cuttitta, F. & Zudaire, E. eds. The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications, Springer Press

Ghosh K, Thodeti CK and Ingber DE (2011, in press). Micromechanical Design Criteria for Tissue Engineering Biomaterials. In: Ratner, B., Hoffman, A,. Schoen, F. & Lemons, J., eds. Biomaterials Science: An Introduction to Materials in Medicine - 3rd edition, Elsevier Academic Press.

Boris Baibakov, Lyn Gauthier,P. Talbot, Tracy L. Rankin and Jurrien Dean. Sperm binding to the zona pellucida is not sufficient to induce acrosome exocytosis. Development 134, 933-943 (2007) doi:10.1242/dev.02752

Pan Z, Ghosh K, Liu Y, Nakamura T, Clark RAF, Rafailovich MH. (2009) Traction stresses and translational distortion of the nucleus during fibroblast migration on a physiologically relevant ECM mimic. Biophysical Journal; 96(10): 4286-4298

Ghosh K, Thodeti CK, Dudley AC, Mammoto A, Klagsbrun M, Ingber DE. (2008) Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro. Proceedings of the National Academy of Sciences USA; 105(32): 11305-11310.

Ghosh K, Pan Z, Guan E, Ge S, Liu Y, Nakamura T, Ren X-D, Rafailovich M, Clark RAF. (2007) Cell adaptation to a physiologically relevant ECM mimic with different viscoelastic properties. Biomaterials; 28(4): 671-679

Ji Y, Ghosh K, Shu XZ, Li B, Sokolov JC, Prestwich GD, Clark RAF, Rafailovich MH. (2006) Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds. Biomaterials; 27: 3782-3792

Ghosh K, Ren X-D, Shu XZ, Prestwich GD, Clark RAF. (2006) Fibronectin functional domains coupled to hyaluronan stimulate adult human dermal fibroblast responses critical for wound healing. Tissue Engineering; 12 (3): 601-613

Ghosh K, Shu XZ, Mou R, Lombardi J, Prestwich GD, Rafailovich MH, Clark RAF. (2005) Rheological characterization of in situ crosslinkable hyaluronan hydrogels. Biomacromolecules; 6: 2857-2865.
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