Research Specialization - The research in this laboratory addresses two overlapping questions of the transmembrane signal transduction processes. 1. Using biophysical methods, we study the role of physicochemical parameters of lipid bilayer membranes in the signal transduction process, primarily in modulating protein kinase C. 2. On a cellular level, we are elucidating the details of signal transduction pathways leading to activation of brain endothelial cells by various stimuli with the goal of developing novel anti-angiogenesis therapies against cancer.
Our laboratory studies modulation of angiogenesis as a potential therapy in a variety of diseases, including stroke. Angiogenic processes are known to ameliorate effects of stroke, creating an alternative blood supply to bypass stroke-damaged blood vessels. We are exploring a possibility to induce the homing of embryonic stem cells to ischemic region following stroke. Administration of chemoattractants at the site of ischemic lesion may induce stem cells migration to the site of injury. Human embryonic stem cells have the potential to differentiate into a variety of cell type which compose blood vessels, including endothelial cells, smooth muscle cells, and pericytes, thus having a potential to enhance the growth of collatoral blood vessels, increasing the rate of recovery and decreasing neuronal damage following cerebral ischemia.
More information on the Zidovetzki Lab
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